牙周组织炎症的发生和发展是定植于牙周袋中的致病菌与宿主免疫和炎症反应相互作用的结果。牙龈卟啉单胞菌是革兰阴性的专性厌氧菌,该菌具有一系列逃避宿主防御机制及破坏宿主组织的毒性因子,如菌毛、多糖夹膜、脂多糖、外膜膜泡和多种蛋白酶[1],是目前公认的慢性牙周炎重要的病原菌,与牙周炎症的发生、发展和复发密切相关[2~4]。 The occurrence and development of periodontal inflammation results from the interaction of pathogenic bacteria colonized in the periodontal pocket with host immune and inflammatory responses. Porphyromonas gingivalis is a Gram-negative obligate anaerobe that has a series of virulence factors that evade host defense mechanisms and disrupt host tissues such as pili, polysaccharide jelly, lipopolysaccharide, epicardial vesicles and A variety of proteases [1], is now recognized as an important pathogens of chronic periodontitis, and periodontitis is closely related to the occurrence, development and recurrence [2 ~ 4].