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Ⅰ类抗心律失常药物对心肌细胞的钠通道都具有频率依赖性的阻滞作用(RDB)。本文综述研究RDB开始及恢复动力学的方法,RDB产生的机制及影响RDB动力学过程的因素,并从RDB的角度出发讨论Ⅰ类药物的细分类及其意义。
Class I antiarrhythmic drugs have a frequency-dependent block (RDB) of cardiomyocyte sodium channels. This article reviews the methods of RDB initiation and recovery kinetics, the mechanism of RDB production and the factors that influence RDB kinetics process, and discusses the subdivision and significance of class I drugs from the perspective of RDB.