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【目的】观察牛蛙腐皮红腿症的病理学改变。【方法】通过石蜡切片,H.E染色法,对发生腐皮红腿症的牛蛙自然病例进行病理形态学变化观察。【结果】剖检发现病蛙头、背部皮肤腐烂,露出肌肉,腹部及腿部皮肤出血发红;肝肿大,严重充出血,呈花瓣状;脾、肾出血肿大,颜色加深;胃肠道黏膜出血发红,内充满大量淡黄色黏液。镜检以全身多组织器官充出血、实质细胞变性、坏死及炎症细胞浸润为主要特征,以皮肤肌肉、肝、脾、肾和胃肠道的变化最为明显。胃肠道表现为严重的出血性、卡他性炎症,胃肠黏膜上皮严重坏死、脱落;肝细胞严重空泡变性,并出现大面积坏死,肝间质充满大量炎症细胞;脾脏淋巴细胞、网状内皮细胞严重坏死;肾间质充血,肾小管上皮细胞广泛坏死,肾小球毛细血管严重充血。【结论】头背部体表皮肤溃烂,腹部及四肢出血,肝、脾、肾、胃肠道等多器官组织炎性病变是本病的示病症状。机体多器官组织严重病变是引起病蛙死亡的主要因素。
【Objective】 To observe the pathological changes of red-legged bullfrog skin. 【Method】 Pathological changes of natural bullfrogs were observed by paraffin sections and H.E staining. [Results] The diseased head and the skin on the back were found decayed and muscle was revealed by autopsy. The bleeding on the abdomen and leg skin was red. The hepatomegaly was swollen and the blood was petal-like. The spleen and kidney hemorrhage were swollen and the color deepened. Road mucosal bleeding red, filled with a large number of pale yellow mucus. Microscopic examination of the whole body multi-tissue organs filled with blood, parenchymal cell degeneration, necrosis and inflammatory cell infiltration as the main feature of the skin and muscle, liver, spleen, kidney and gastrointestinal changes most obvious. Gastrointestinal manifestations of severe hemorrhagic catarrhal inflammation, severe gastrointestinal mucosal necrosis, shedding; severe degeneration of hepatocytes, and a large area of necrosis, liver mass is filled with a large number of inflammatory cells; spleen lymphocytes, the network Severe endothelial cell necrosis; renal interstitial congestion, tubular necrosis extensively, glomerular capillary congestion. 【Conclusion】 The head and back body surface skin ulceration, abdominal and limbs bleeding, liver, spleen, kidney, gastrointestinal tract and other organ tissue inflammatory lesions is the disease symptoms. Serious organo-organ tissue damage is the main cause of death of the frog.