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目的调查某医院住院患者泌尿系大肠埃希菌感染的临床分布及耐药性变化。方法取2014年1月-2015年12月某医院各科室送检泌尿系感染的住院患者尿标本进行培养鉴定及药物敏感性分析。结果泌尿系感染的尿标本中共分离出大肠埃希菌981株,其中产ESBLS组为634株,阳性率为64.63%,主要分布在泌尿外科、肾内科和神经外科。产ESBLS组对亚胺培南、美罗培南的耐药率为0%,对大多数抗菌药物的耐药率明显高于非产ESBLS组(P<0.05)。结论加强医院泌尿系感染住院患者的尿标本培养监测及其耐药性检测,可指导临床合理应用抗菌药物。
Objective To investigate the clinical distribution and drug resistance of urinary Escherichia coli inpatients in a hospital. Methods From January 2014 to December 2015, the hospital urine samples from urinary tract infection in various departments of a hospital were collected for identification and drug sensitivity analysis. Results There were 981 Escherichia coli isolates isolated from urinary tract infection. Among them, 634 ESBLS patients were found, the positive rate was 64.63%. They were mainly distributed in urology, nephrology and neurosurgery. The drug resistance rate of ESBLS group to imipenem and meropenem was 0%, and the resistance rate to most antibiotics was significantly higher than that of ESBLS group (P <0.05). Conclusion In order to strengthen the monitoring of urinary specimens in hospitalized patients with urinary tract infection and the detection of their drug resistance, it can guide the rational use of antibacterials in clinic.