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Oxidative stress leads to lipid peroxidation and may contribute to the pathoge nesis of lesions in multiple sclerosis (MS), an autoimmune disease characterised by inflammatory as well as degenerative phenomena. We previously found that cer ebrospinal fluid (CSF) levels of isoprostane 8 epi PGF 2α,a marker of free ra dical damage and lipid peroxidation in vivo, were elevated in MS patients. Such levels were correlated with the degree of disability and reduced in subjects und er steroid therapy. Here we investigated weather the CSF isoprostane levels corr elated with disease inflammatory activity. To this aim, we enrolled 41 relapsing remitting (RR) MS patients who underwent at the same time full neurological ex amination, NMR imaging brain scan and diagnostic CSF test. No evidence of corre lation was found between 8 epi PGF2α.levels and the presence of gadolinium (G d) enhancing NMR lesions or the time elapsed since the last relapse. We suggest that isoprostanes are not useful as surrogate inflammatory markers in MS. Howev er, they may represent a sensitive index of degenerative phenomena, which can pe rsist also in the absence of inflammatory activity. 2004 Elsevier B.V. All right s reserved.
Oxidative stress leads to lipid peroxidation and may contribute to the pathoge nesis of lesions in multiple sclerosis (MS), an autoimmune disease characterised by inflammatory as well as degenerative phenomena. We previously found that cer ebrospinal fluid (CSF) levels of isoprostane 8 epi PGF 2α, a marker of free ra dical damage and lipid peroxidation in vivo, were elevated in MS patients. Such levels were correlated with the degree of disability and reduced in subjects und er steroid therapy. Here we investigated weather the CSF isoprostane levels corr elated with disease inflammatory activity. To this aim, we enrolled 41 relapsing remitting (RR) MS patients who underwent at the same time full neurological exmination, NMR imaging brain scan and diagnostic CSF test. No evidence of occlusion was found between 8 epi PGF2α. Levels and the presence of gadolinium (G d) -enhancing NMR lesions or the time elapsed since the last relapse. We suggest that isoprostanes are not useful as surr Howev er, they may represent a sensitive index of degenerative phenomena, which can pe rsist also in the absence of inflammatory activity. 2004 Elsevier B.V. All right s reserved.