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磁性纳米粒不仅具有纳米粒的特性,还具有磁导向作用,因此在药学方面有着广泛的应用,特别是在磁靶向制剂方面。纳米粒的制备通常采用化学方法,这样得到的粒子表面光滑、性能均一,然后将纳米粒镶嵌在母体里进行药物的装载,最后通过磁性导向定位,并且还可以在母体的表面黏结一些大分子化合物,如蛋白受体。随着材料科学和药学的发展,磁性纳米粒越来越受到研究人员的重视。文中主要介绍了磁性纳米粒的合成和磁靶向制剂的概念,并探讨磁性纳米粒的最新临床应用。
Magnetic nanoparticles not only have the characteristics of nanoparticles, but also have a magnetic orientation, it has a wide range of applications in medicine, especially in magnetic targeting agents. The preparation of the nanoparticles usually adopts a chemical method, so that the particles obtained are smooth in surface and uniform in performance, and then the nanoparticles are embedded in the matrix for drug loading and finally orientated by magnetic guidance, and the macromolecular compound can also be bound on the surface of the matrix , Such as protein receptors. With the development of materials science and pharmacy, magnetic nanoparticles have attracted more and more researchers’ attention. This paper mainly introduces the concept of magnetic nanoparticles synthesis and magnetic targeting agents, and discusses the latest clinical application of magnetic nanoparticles.