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为了研究乙肝疫苗接种无弱应答的发生机制，本次研究首先对经过严格筛选的无弱应答和强应答（对照）者一级亲属（分别有８０和７９人）自然状况下的ＨＢＶ感染率进行比较。结果显示，无弱应答组ＨＢＶ的感染率为３３．８％，明显高于强应答组的１５．２％（Ｐ＝０．０１１）。在此基础上，进一步观察了无弱应答和强应答组一组亲属中乙肝三项指标全阴性和单项抗－ＨＢｓ低水平者５６人（分别为２７和２９人）接种乙肝疫苗后Ｔ７时抗－ＨＢｓ的分布情况，两组分别随访到２４人和２８人，结果无弱应答组的ＧＭＴ显著低于强应答组的ＧＭＴ。表明无弱应答具有一定的遗传易患性。
In order to investigate the mechanism of a non-lethal response to hepatitis B vaccination, this study first examined the HBV infection rate under natural conditions in closely matched first-degree relatives (80 and 79, respectively) of non-responders and responders (controls) Compare The results showed that the infection rate of HBV in the no-weak response group was 33.8%, significantly higher than that of the strong response group 15.2% (P = 0.011). On this basis, we further observed that in a non-responder and a strong responder group, 56 (27 and 29, respectively) were negative for all three HBs and low for single anti-HBs with T7 antibody after hepatitis B vaccination -HBs distribution, the two groups were followed up to 24 and 28, the results of the GMT was significantly lower than the strong response group GMT. That weak response has some genetic susceptibility.