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作者从2500存活株中分得五株β-内酰胺抗生素生物合成障碍变株。对其使青霉素 N 扩环成头孢菌素的能力进行了测试。在深层培养条件下,变株 M-0198,M-0109,M-2351不产生β-内酰胺抗生素
The authors obtained five strains of β-lactam antibiotic biosynthesis disorders from 2500 surviving strains. Its ability to expand penicillin N into cephalosporins was tested. Under deep culture conditions, mutants M-0198, M-0109 and M-2351 did not produce β-lactam antibiotics