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从４０年间１０００例老年尸检中选肾损害有明确病理诊断的病例２８８例，男性１６５例、女性１２３例，年龄６０～９５岁，平均７２．７６岁。结果：１、肾功损害程度与死因关系：（１）尚能代偿，非直接死于肾疾病者１８４例；（２）失代偿期，出现慢性肾衰，肾疾病是死因之一者６０例；（３）终末期肾，直接死于尿毒症者４４例。２、常见慢性肾功不全的肾疾病分类：（１）肾血管为主肾疾病１１８例（４１％）；（２）肾实质小球改变为主肾疾病７６例（２６．５％）；（３）肾小管及肾间质为主肾疾病７１例（２４．５％）；（４）尿道肿瘤及畸形２３例（８％）．３、慢性肾功不全的病理：肾体积、肾重量减少，肾小球透明变，电镜上皮细胞足突消失，基底膜有电子高密度沉积物，肾小管坏死，间质纤维化等改变。
One hundred and eighty-eight cases with clear pathological diagnosis of renal damage were selected from 1000 elderly autopsy in 40 years. There were 165 males and 123 females, aged from 60 to 95 years, with an average of 72.76 years. (1) 184 patients who can still be compensated and died of kidney disease directly; (2) Chronic renal failure, renal failure is one of the causes of death due to decompensation 60 cases; (3) terminal renal, directly died of uremia in 44 cases. 2, common chronic renal insufficiency renal disease classification: (1) Renal vascular disease in 118 cases (41%); (2) renal parenchymal glomerular changes to 76 cases of primary kidney disease (26.5%); ( 3) 71 cases (24.5%) of renal tubules and renal interstitium were primary renal diseases; (4) 23 cases (8%) of urethral tumors and deformities. 3, pathology of chronic renal insufficiency: renal volume, weight loss of kidney, glomerular transparency changes, disappearance of electron microscopy foot cell processes, the basement membrane electron density deposits, tubular necrosis, interstitial fibrosis and other changes.