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本文对9例足月新生儿死亡的新鲜肾上腺组织进行了电镜检查。根据激素应用与否分为激素组5例,对照组4例,观察短期(3～6天)大剂量激素(地塞米松0.25～0.5 mg/kg/天)治疗对新生儿肾上腺皮质束状带细胞超微结构的影响。电镜下示激素组肾上腺皮质束状带外层细胞线粒体含嵴数量减少,出现大量管状嵴,可见退变的巨大线粒体:滑面内质网平滑膜管减少,有些则呈串孢状扩张,腔内含有紫状物:类脂滴体积扩大,密度坛加。上述改变说明即使是短期应用大剂量激素治疗亦可致新生儿HPA轴抑制,肾上腺皮质功能减退。
In this paper, 9 cases of full-term neonatal death of fresh adrenal tissue electron microscopy. According to the application of hormones, we divided them into hormone group (n = 5) and control group (n = 4). The effects of short-term high dose of 3-6 days dexamethasone (0.25-0.5 mg / Effect of cell ultrastructure. Under the electron microscope, the mitochondria cristae were reduced in the outer layer of the cortical fascia of the adrenal cortex, and a large number of tubular ridges were found. The degenerated giant mitochondria showed a decrease in the smooth membrane of the smooth endoplasmic reticulum, Contains purple: lipid droplets expand the size of the altar plus. These changes indicate that even short-term high-dose hormone therapy can also cause neonatal HPA axis inhibition, adrenal insufficiency.