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目的:探讨高危型人乳头状瘤病毒(HPV)的负荷量与宫颈病变程度的相关性以及高危型HPV测定在宫颈病变治疗后患者中的随访监管作用。方法:采用HC-2的方法对2009~2010年在新疆医科大学附属肿瘤医院就诊的361例患者进行高危型HPV负荷量的测定,其中宫颈鳞癌76例、宫颈上皮内瘤变(CIN)119例、宫颈炎166例;对高危型HPV的负荷量与宫颈病变程度进行相关分析,并对治疗后的CIN及宫颈鳞癌患者随访至2013年12月,随访时间37~60个月。结果:高危型HPV负荷量在宫颈炎、CIN及宫颈鳞癌3组人群中比较差异有统计学意义(P<0.01),其随宫颈病变程度的加重而增加,呈正相关(r=0.436,P=0.000)。随访中发现阴道上皮内瘤变6例,CIN再发3例,外阴阴道鳞状细胞癌1例,与阴道内持续高危HPV感染有关。结论:高危型HPV的负荷量与宫颈病变的程度呈正相关,并在宫颈病变治疗后患者的监管中有重要的作用。
Objective: To investigate the correlation between the load of high risk human papillomavirus (HPV) and the degree of cervical lesion, and to monitor the follow-up of high-risk HPV in patients after cervical lesion. Methods: The HC-2 method was used to measure the high-risk HPV load in 361 patients who were treated in Cancer Hospital Affiliated to Xinjiang Medical University from 2009 to 2010. There were 76 cases of cervical squamous cell carcinoma and 119 cases of cervical intraepithelial neoplasia Cases, cervicitis 166 cases; high-risk type of HPV load and cervical lesions were analyzed, and after treatment of CIN and cervical squamous cell carcinoma patients were followed up to December 2013, the follow-up time was 37 to 60 months. Results: The incidence of high-risk HPV in cervicitis, cervical intraepithelial neoplasia and cervical squamous cell carcinoma was significantly different (P <0.01), which was positively correlated with the severity of cervical lesions (r = 0.436, P = 0.000). Follow-up found in 6 cases of vaginal intraepithelial neoplasia, CIN recurrence in 3 cases, 1 case of vulvar and vaginal squamous cell carcinoma, and persistent high risk of HPV infection in the vagina. Conclusion: The load of high-risk HPV is positively correlated with the degree of cervical lesions and plays an important role in the regulation of patients after cervical lesions.