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目的探讨妊娠高血压综合征患者孕中、晚期血清瘦素的变化及其临床意义。方法采用放射免疫法测定30例妊高征孕妇(研究组)和50例正常孕妇(对照组)孕中、晚期的血清瘦素水平,并对其结果进行相关性分析。结果两组孕妇随着孕周增加瘦素水平呈上升趋势,妊高征组孕妇的血清瘦素水平明显高于正常孕妇;孕中期妊高征妇女的瘦素水平明显高于正常妊娠妇女;妊高征孕妇血清瘦素水平与收缩压、舒张压均呈正相关。结论妊高征与瘦素关系密切,妊高征孕妇孕中期瘦素水平明显高于正常孕妇,其作为预测妊高征指标有一定意义。
Objective To investigate the changes and clinical significance of serum leptin in the second and third trimester of pregnancy induced hypertension syndrome. Methods Serum leptin level was measured by radioimmunoassay in 30 pregnant women with PIH (study group) and 50 normal pregnant women (control group), and their correlations were analyzed. Results The levels of leptin increased with the gestational age in both groups. The serum leptin levels in pregnant women with PIH were significantly higher than those in normal pregnant women. The levels of leptin in pregnant PIH women were significantly higher than those in normal pregnant women High serum leptin levels in pregnant women with systolic and diastolic blood pressure were positively correlated. Conclusions Pregnancy-induced hypertension is closely related to leptin. The level of leptin during the second trimester of pregnancy-induced hypertension is significantly higher than that of normal pregnant women. It has some significance as an index to predict pregnancy-induced hypertension.