论文部分内容阅读
采用戊四氮（ｐｅｎｔｙｌｅｎｅｔｒａｚｏｌ，ＰＴＺ）诱发大鼠癫痫模型，用苯妥因（ｐｈｅｎｙｔｏｉｎ，ＰＨＴ）预处理大白鼠，用放免法测定各组大鼠额叶皮层及海马中ｃＡＭＰ、ｃＧＭＰ的含量。结果发现：预处理组额叶皮层ｃＡＭＰ、ｃＧＭＰ与癫痫组中相应指标显著下降，海马ｃＧＭＰ较癫痫组显著下降。提示ＰＨＴ可能控制癫痫是与稳定ｃＡＭＰ、ｃＧＭＰ水平有关
Rats were induced by pentylenetrazol (PTZ) and the rats were pretreated with phenytoin (PHT). The levels of cAMP and cGMP in frontal cortex and hippocampus of rats in each group were determined by radioimmunoassay. The results showed that: pretreatment of the frontal cortex cAMP, cGMP and epilepsy group corresponding index decreased significantly, hippocampal cGMP significantly decreased compared with epilepsy. Tip PHT may control epilepsy and stable cAMP, cGMP level