论文部分内容阅读
为了寻找抗肿瘤候选化合物,根据生物电子n b等排原理,设计合成系列白藜芦醇类似物。以芳香杂环醛和取代甲苯为起始原料,经缩合、脱甲基化反应得标题化合物。通过IR、~1HNMR和~(13)CNMR对目标化合物进行结构确定。采用MTT法对合成的化合物进行体外抗肿瘤活性评价。结果表明,化合物对所测肿瘤细胞有不同的增殖抑制作用,其中E-(2-呋喃)(3,5-二羟基苯基)乙烯、E-(2-吡咯)(3,5-二羟基苯基)乙烯的抗肿瘤活性较突出,高于对照物白藜芦醇,值得进一步研究。
In order to search for anti-tumor candidate compounds, a series of synthetic resveratrol analogues were designed according to the principle of n b isobaric bioenergetics. The aromatic heterocyclic aldehyde and substituted toluene as the starting material, after condensation, demethylation reaction of the title compound. The structures of the target compounds were confirmed by IR, ~ 1HNMR and ~ (13) CNMR. The antitumor activity of the synthesized compounds was evaluated by MTT assay. The results showed that the compounds have different proliferation inhibitory effects on the tested tumor cells, of which E- (2-furan) (3,5-dihydroxyphenyl) ethylene, E- (2-pyrrole) Phenyl) ethylene is more prominent antitumor activity, higher than the control resveratrol, it is worth further study.