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本研究通过氚—胸腺嘧啶核苷放射自显影方法,对30例患者的结肠粘膜细胞动力学及LACA小鼠的结肠上皮细胞移动进行了观察。结果表明,结肠炎与结肠癌的粘膜细胞标记指数(LI)是较高的,以结肠癌最高。部分结肠炎的粘膜增殖区扩大,而结肠癌组织标记细胞则呈弥漫性分布。同时测定本组22例患者的血清CEA水平,认为血清CEA水平可能与细胞增殖率有关,由于病例较少,尚待进一步研究。
In this study, the kinetics of colonic mucosal cells in 30 patients and the colonic epithelial cell movement in LACA mice were observed by autoradiography with thymidine-thymidine. The results showed that the mucosal cell labeling index (LI) of colitis and colon cancer was higher, with the highest colon cancer. The mucosal proliferative zone of some colitis was enlarged, while the colon cancer tissue marked cells were diffusely distributed. At the same time, serum CEA levels were measured in 22 patients in this group. It was considered that the serum CEA level may be related to cell proliferation rate. Because there are few cases, further study is needed.