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在中药麻醉中,肌肉松弛不足是急需解决的问题之一,我们将从东北产防己科植物蝙蝠葛(Menispermun dauicum DC.)根茎中提得的总碱制成季胺块(即甲基山豆根总碱),并进行了药理研究及临床应用,证实该药确具肌松作用,但发现有明显降低血压的缺点。进一步研究,又从总碱中分离得一种新的生物碱——蝙蝠葛苏林碱(Daurisoline简称D_(610)),其结构为:
In the traditional Chinese medicine anesthesia, lack of muscle relaxation is one of the urgent problems to be solved, we will be made from the northeast of the anti-Peter plant genus (Menispermun dauicum DC.) Rhizome made from the total base of quaternary ammonium block (ie, Root total alkali), and pharmacological studies and clinical applications, confirmed that the drug is indeed a muscle relaxant, but found to significantly reduce the shortcomings of blood pressure. Further study, but also from the total alkaloids isolated a new alkaloid - daurisoline (D 610 (610)), its structure is: