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目的:评价叶下珠复方治疗慢性乙型肝炎的疗效。方法:采用该复方(苦味叶下珠、三七等)联合干扰素(100万U肌注,隔天1次)治疗慢性乙型肝炎40例,并与干扰素单用(剂量同前)治疗30例随机对照观察。结果:叶下珠复方联合干扰素组治疗3个月,临床症状改善明显,治疗总有效率为92.5%,肝功能ALT、AST、A/G、SB的复常率分别为70.0%、80.5％、81.3％和77.3％,疗效优于对照组(P<0.05)。叶下珠复方联合干扰素治疗组HBeAg、HBV—DNA阴转率为52.8％、58.8％,与对照组比较(36.0％,39.1%),差异无显著性意义(P>0.05)。结论:叶下珠复方与干扰素联用能提高治疗慢性乙型肝炎的疗效,具有明显的协同作用。
Objective: To evaluate the efficacy of Phyllanthus amazoniae compound in treating chronic hepatitis B Methods: 40 cases of chronic hepatitis B were treated with the compound (Bitter yehliu, Panax notoginseng, etc.) Combined with interferon (1 million U intramuscular injection every other day) and treated with interferon alone (with the same dose) 30 cases of randomized controlled observation. Results: The combination therapy of Phyllanthus followed by interferon for 3 months showed obvious improvement of clinical symptoms, and the total effective rate was 92.5%. The normal rates of liver function ALT, AST, A / G and SB were 70.0% and 80.5% , 81.3% and 77.3%, respectively. The curative effect was better than that of the control group (P <0.05). Phyllis beads combined with interferon treatment group HBeAg, HBV-DNA negative conversion rate was 52.8%, 58.8%, compared with the control group (36.0%, 39.1%), the difference was not statistically significant (P> 0.05). Conclusion: Ye Xia Zhu combined with interferon can improve the efficacy of treatment of chronic hepatitis B, with significant synergies.