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采用给禁食大鼠脑室灌注溶于不同溶剂中的ＧＬＰ－１（７－３６）的方法，观察ＧＬＰ－１在中枢对大鼠血糖及血糖调节激素浓度的影响。结果表明：脑室灌注溶于生理盐水的ＧＬＰ－１与单纯灌注生理盐水相比，血糖无明显变化，但１小时后，血中胰岛素、胰升糖素浓度均明显降低；脑室灌注溶于３０％葡萄糖的ＧＬＰ－１与单纯灌注３０％葡萄糖相比，血糖明显升高，在３０’、４５’、６０’有显著性差异，血中胰岛素浓度明显低于对照组，胰升糖素浓度无变化。这些实验说明ＧＬＰ－１参与了中枢神经系统对胰岛分泌激素功能的调节。
The effect of GLP-1 on the blood glucose and glucose-regulated hormones in rats was observed by perfusing GLP-1 (7-36) dissolved in different solvents into the ventricles of rats. The results showed that GLP-1 dissolved in physiological saline had no significant change in blood glucose compared with normal saline, but the concentration of insulin and glucagon in blood decreased significantly after 1 hour. Glucose GLP-1 compared with the simple perfusion of 30% glucose, blood glucose was significantly increased at 30 ’, 45’, 60 ’have significant differences in blood insulin levels were significantly lower than the control group, no change in glucagon concentration . These experiments demonstrate that GLP-1 is involved in the regulation of insulin secretion hormone function by the central nervous system.