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目的 :探讨果胶铋、雷尼替丁、痢特灵和四环素每日服 2次 ,2周疗法对确诊为幽门螺杆菌 (Helicobacterpy lori ,HP)阳性的十二指肠溃疡的疗效及费用分析。方法 :60例农村患者随机分成四联疗法组 ( 30例 )和新三联 (由奥美拉唑、克拉霉素、甲硝唑组成 )疗法组 ( 30例 ) ,服药前及停药 4周行胃镜检查和组织活检。结果 :改良果胶铋四联疗法的溃疡愈合率、HP根除率和不良反应出现率分别为 93.3%、86.7%和 2 0 .0 % ,而新三联组则分别为 96.6%、90 .0 %和16.6% ,2组比较均无显著差异 (P >0 .0 5 )。结论 :由雷尼替丁、果胶铋、痢特灵和四环素组成的每日服药 2次 ,连服 2周的四联疗法 ,对HP阳性十二指肠溃疡疗效好 ,价格便宜 ,适合山区农村医院推广。
Objective: To investigate the curative effect and cost analysis of pectin bismuth, ranitidine, furazolidone and tetracycline administered twice a day for 2 weeks in patients with Helicobacter pyrolus positive duodenal ulcer . Methods: Sixty rural patients were randomly divided into quadruple therapy group (30 cases) and neo-triple therapy group (30 cases) consisting of omeprazole, clarithromycin and metronidazole. Before treatment and discontinuation for 4 weeks Gastroscopy and biopsy. Results: The rates of ulcer healing, HP eradication and adverse reactions were 93.3%, 86.7% and 20.0% respectively in the modified pectin bismuth quadruple therapy group compared with 96.6% and 90.0% in the new triad group, respectively And 16.6% respectively. There was no significant difference between the two groups (P> 0.05). Conclusion: The combination of ranitidine, pectin bismuth, furazolidone and tetracycline twice a day, and even for 2 weeks of quadruple therapy, HP-positive duodenal ulcer effective, cheap, suitable for mountainous areas Rural hospital promotion.