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为探讨生长抑素对肝脏转移性结肠腺癌的抑制作用,采用流式细胞术观察生长抑素衍生物SMS201-995对BALB/C小鼠结肠腺癌(CT26)肝脏转移瘤生长的抑制作用。结果表明:与对照组相比,治疗组小鼠肝转移瘤细胞增殖指数和S期分数明显降低,而GO/Gl期分数却显著增加,同时治疗组小鼠体重降低明显延缓,肝脏转移瘤数目显著减少,生存期明显延长。因此,生长抑素对抑制结肠癌肝转移瘤的生长具有一定的作用。
To investigate the inhibitory effect of somatostatin on hepatic metastatic colon adenocarcinoma, the inhibitory effect of somatostatin derivative SMS201-995 on hepatic metastasis of colon adenocarcinoma (CT26) in BALB/C mice was observed by flow cytometry. The results showed that: compared with the control group, the proliferation index and S-phase score of the hepatic metastatic tumor cells in the treatment group were significantly reduced, while the GO/Gl phase score was significantly increased. At the same time, the weight loss of the treatment group mice was significantly delayed, the number of hepatic metastases Significantly reduced, significantly longer survival. Therefore, somatostatin has a certain effect on inhibiting the growth of liver metastases of colon cancer.