我们对比了家兔服用红霉素或苯巴比妥前、后氨茶硷药代动力学的变化。其中5只家兔在服用红霉素7天的前、后分别静脉注射氨茶硷25mg/kg;另外6只家兔在口服苯巴比妥14天的前、后分别静脉注射氨茶硷25mg/kg。在氨茶硷每次注射后的6小时内,分次取血清标本检测。结果表明,红霉素明显减少氨茶硷的清除率(P<0.001),并增加t(1/2)(P<0.05);苯巴比妥明显增加氨茶硷清除率(P<0.01),并减少t(1/2)(P<0.05)。 We compared the rabbits before taking erythromycin or phenobarbital before and after aminophylline pharmacokinetics changes. Among them, 5 rabbits received intravenous aminophylline 25mg / kg before and after taking erythromycin for 7 days. The other 6 rabbits were given intravenous aminophylline 25mg before and after 14 days of oral phenobarbital / kg. In ammonia aminophylline within 6 hours after each injection, serum samples were taken for testing. The results showed that erythromycin significantly reduced the clearance rate of aminophylline (P <0.001) and increased t (1/2) (P <0.05), and phenobarbital significantly increased the clearance rate of aminophylline (P <0.01) , And reduced t (1/2) (P <0.05).