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穿越肠道主要障碍是消化酸液与酶会在药物到达目的地之前 ,就将药物分解 ;药物要穿过肠壁也有困难。解决方法 :(a)为药物包覆上一层生物黏附聚合物 ,以帮助药物结合到肠壁上并挤进细胞间隙 ;(b)将药物链上导引分子———专门针对肠细胞表面的受体 ,以方便药物被肠细胞吸收 ;(c)
The main obstacle to crossing the intestine is digestion of acid and enzymes that break down the drug before it reaches its destination. Drugs also have difficulty traversing the intestinal wall. Solution: (a) Cover the drug with a layer of bioadhesive polymer to help bind the drug to the intestinal wall and into the interstitial space; (b) Route the drug on the guide molecule-specifically to the intestinal cell surface Of the receptor to facilitate the absorption of drugs by intestinal cells; (c)