大剂量应用异环磷酰胺(IFF)可引起肾脏损害,以出血性膀胱炎最为常见。Dyk 等人对31例病人一次性应用 IFF(150mg/kg)时,66%的患者出现氮质血症,10%血肌酐急剧升高。另一些研究者注意到,应用大剂量 IFF 产生肾毒性,出现成人范可尼氏综合征,即全身性酸中毒、低血钾、蛋白尿及异常尿电解质丢失。通过分次给药法可消除对肾脏的损害。本文作者报告分次给予 IFF 治疗复发恶性淋巴瘤患者也出现了肾功能异常。病人和方法 4例复发恶性淋巴瘤患者,给予 IFF1.25g/m~2/天,静滴4小时以上,5天为一疗程,并同时应用利尿剂。治疗前、中、后分别化验血,治疗后每天查尿排泄物的酸 High-dose ifosfamide (IFF) can cause kidney damage, the most common hemorrhagic cystitis. When Dyk et al. Administered a single IFF (150 mg / kg) to 31 patients, azotemia occurred in 66% of patients and a sharp increase in serum creatinine was found in 10%. Other researchers noticed that the use of high-dose IFF produces nephrotoxicity and presents with adult-onset Fanconi’s syndrome, systemic acidosis, hypokalemia, proteinuria and abnormal urinary electrolyte loss. Through the sub-administration method can eliminate the damage to the kidneys. The authors report that IFF treatment of recurrent malignant lymphoma patients also appeared renal dysfunction. Patients and Methods Four patients with recurrent malignant lymphoma were given IFF 1.25 g / m ~ 2 / day for more than 4 hours, 5 days for one course of treatment and diuretic. Blood tests were performed before, during and after treatment, and urine excretion was checked daily