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甲咪硫脲(Metiamide)是一种组织胺H_2受体的拮抗剂,近年来已用于临床,对十二指肠溃疡的近期疗效是肯定的,可使短期内愈合。本文报告用甲咪硫脲分组治疗32例经内窥镜证实的活动性十二指肠溃疡病人,旨在研究该药在长期使用过程中及停药以后对本病的复发和自然病程的影响。治疗分成3组。Ⅰ组(20例):甲咪硫脲1克/天,分次口服,治疗1月,以后本组再分成甲组(8例)减量夜间服药(400毫克,每晚1次),和乙组(12例)用安慰剂。Ⅱ组(即丙组,7例):足量长期治疗(甲咪硫脲0.8或1克/天,昼夜分次服,共4～15月)。Ⅲ组(即丁组,
Metiamide is a histamine H 2 receptor antagonist, has been used in clinical practice, the immediate effect of duodenal ulcer is affirmative, can make the short-term healing. This article reports the use of meflamidine subgroups of 32 patients with endoscopic confirmed active duodenal ulcer patients to study the drug in the long-term use and after stopping the recurrence of the disease and the natural course of the impact . The treatment is divided into 3 groups. Group Ⅰ (20 cases): mevalonate thiourea 1 g / day orally, for 1 month, after this group was subdivided into Group A (8 cases) reduced nighttime medication (400 mg once night), and Group B (12 cases) with placebo. Group Ⅱ (Group C, n = 7): adequate long term treatment (carbamethionil 0.8 or 1 g / day, day and night divided doses, 4-15 months). Group Ⅲ (ie, group D,