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对氟喹酮的合成及其广谱和强大的体外抗菌活性的研究不断发展,最近已将注意力集中到这些药物的副作用上。一般来说,这些药物是安全的,能为患者较好耐受,总的副作用发生率为5～25%。幸而大多数副作用仅轻至中度,因药物毒性需中止治疗者仅1～3%。胃肠道副作用最常见,5～20%的患者发生厌食或恶心,但症状常为轻微和暂时的。腹痛、呕吐或腹泻发生率仅为3～5%,但症状可能较为严重以至于需中止治疗。中枢神经系统刺激症状如烦躁、神经过敏、失眠、欣快感和震颤的发生率为1～5%,非特异性反应如头痛、眩晕和精神错乱也有发生,但其和所用药物
The development of fluoroquinolone and its broad-spectrum and potent in vitro antibacterial activity have evolved and recent attention has been focused on the side effects of these drugs. In general, these drugs are safe and well tolerated by patients with a total incidence of side effects of 5-25%. Fortunately, most side effects are mild to moderate, requiring only 1 to 3% discontinuation due to drug toxicity. The most common gastrointestinal side effects, 5 to 20% of patients with anorexia or nausea, but the symptoms are often mild and temporary. The incidence of abdominal pain, vomiting or diarrhea is only 3 to 5%, but the symptoms may be so severe that treatment is discontinued. Central nervous system irritation symptoms such as irritability, nervousness, insomnia, euphoria and tremor were the incidence of 1 to 5%, non-specific reactions such as headache, dizziness and mental disorders have occurred, but its and the use of drugs