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目的观察双歧杆菌联合香菇多糖治疗肝硬化患者的效果。方法肝硬化患者在接受常规保肝治疗的同时予口服双歧杆菌活菌胶囊联合香菇多糖胶囊。观察随访4周,治疗前后均抽取静脉血检测。采用常规方法检测肝功能;ELISA方法检测IFN-γ和IL-10水平的变化,流式细胞仪检测CD4/CD8细胞亚群的数量变化。结果临床一般状况明显好转,治疗前后部分肝功能指标明显改善。肝硬化组治疗前外周血CD4+T细胞数量和IFN-γ水平均显著低于正常对照组,治疗后二者明显升高,与治疗前相比差异有显著性。另外,与治疗前组相比,IL-10的水平治疗后明显降低。结论对于肝硬化患者,如果出现了明显的菌群失调伴随免疫功能低下者,宜采用微生态制剂联合免疫增强剂辅助治疗,临床效果较好。
Objective To observe the efficacy of Bifidobacterium combined with lentinan in the treatment of patients with liver cirrhosis. Methods Patients with cirrhosis received oral Bifidobacterium viablensis combined with lentinan while receiving conventional hepatoprotective therapy. Follow-up observation 4 weeks, before and after treatment were drawn venous blood test. The liver function was detected by routine methods. The levels of IFN-γ and IL-10 were detected by ELISA. The changes of CD4 / CD8 subsets were detected by flow cytometry. Results The general clinical condition improved significantly, before and after treatment some of the indicators of liver function improved significantly. The number of CD4 + T cells and the level of IFN-γ in the peripheral blood of cirrhotic patients before treatment were significantly lower than those of the normal control group. The levels of CD4 + T cells and the levels of IFN-γ in cirrhotic patients were significantly higher than those before treatment. In addition, the level of IL-10 was significantly reduced after treatment compared to the pretreatment group. Conclusion For patients with cirrhosis, if there is a clear flora with immune dysfunction, should use probiotics combined with immune enhancer adjuvant therapy, the clinical effect is better.