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目的探讨前列地尔联合还原型谷胱甘肽治疗急性肾损伤(AKI)的疗效。方法 60例急性肾损伤患者,随机分为对照组与治疗组,各30例。对照组采用常规治疗联合还原型谷胱甘肽治疗。治疗组在对照组治疗的基础上加用前列地尔治疗,比较两组患者的治疗效果。结果对照组治愈8例,好转12例,无效10例,总有效率为66.7%;治疗组治愈10例,好转16例,无效4例,总有效率为86.7%。治疗组总有效率显著高于对照组,差异有统计学意义(P<0.01)。治疗组患者的少尿期、多尿期、血肌酐恢复时间均显著短于对照组,差异有统计学意义(P<0.05或0.01)。结论前列地尔联合还原型谷胱甘肽治疗急性肾损伤具有确切疗效,对改善肾功能方面具有积极治疗作用,可有效提高治愈率。
Objective To investigate the curative effect of alprostadil combined with reduced glutathione on acute kidney injury (AKI). Methods Sixty patients with acute renal injury were randomly divided into control group and treatment group, with 30 cases in each group. Control group with conventional treatment combined with reduced glutathione treatment. Treatment group in the control group based on the treatment with alprostadil treatment, the treatment effect of two groups were compared. Results The control group was cured in 8 cases, improved in 12 cases, ineffective in 10 cases, the total effective rate was 66.7%. The treatment group was cured in 10 cases, improved in 16 cases, 4 cases were ineffective, the total effective rate was 86.7%. The total effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P <0.01). The oliguria period, polyuria period, and serum creatinine recovery time in treatment group were significantly shorter than those in control group, with significant difference (P <0.05 or 0.01). Conclusions Alprostadil combined with reduced glutathione has definite curative effect in the treatment of acute kidney injury and has an active therapeutic effect on improving renal function, which can effectively improve the cure rate.