编者按卒中以其高发病率、高致残率和高死亡率严重威胁着人类的健康。越来越多的研究证实炎性因素贯穿于卒中的发生、发展和预后的全过程。动脉粥样硬化是缺血性卒中最常见的病因,动脉粥样硬化斑块的形成、发展、破裂进而导致脑梗死与病原体感染负荷和炎症反应密切相关。缺血性卒中初期的级联反应即有转录因子的合成以及炎症介质的产生,参与了脑梗死病理生理的过程。大量临床和实验研究表明,许多细胞因子包括白介素家族、肿瘤坏死因子等,以及超敏C反应蛋 Editor’s note: Stroke is a serious threat to human health with its high morbidity, high morbidity and mortality. More and more studies confirm that inflammatory factors run through the whole process of stroke occurrence, development and prognosis. Atherosclerosis is the most common cause of ischemic stroke. The formation, development and rupture of atherosclerotic plaque lead to cerebral infarction closely related to the pathogen infection burden and inflammation. The initial cascade of ischemic stroke is the synthesis of transcription factors and the production of inflammatory mediators involved in the pathophysiology of cerebral infarction. Numerous clinical and experimental studies have shown that many cytokines include interleukin family, tumor necrosis factor, etc., as well as hypersensitive C-reactive protein