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松果菊苷是一种从肉苁蓉中分离得到的苯乙醇苷类化合物,前期研究结果表明其有延缓人成纤维细胞衰老的作用。为了阐明松果菊苷抗衰老的机制,我们对相关基因p53,p16,p21及Rb的mRNA及蛋白水平的表达进行了检测,结果表明用松果菊苷处理后,衰老的人成纤维细胞(MRC-5)p53的表达被下调,且呈剂量依赖方式。进一步的研究显示可能和SIRT1白的上调有关。分子对接模拟结果显示松果菊苷的作用可能优于另一公认的抗衰老剂白藜芦醇。松果菊苷可能是一种潜在的可以调控细胞衰老的化合物。
Echinacoside is a phenylethanoid glycoside compound isolated from Cistanche tuberosum, the results of previous studies have shown that it has delayed the role of human fibroblasts. In order to elucidate the anti-aging mechanism of echinacosin, we examined the mRNA and protein expression of p53, p16, p21 and Rb genes. The results showed that the aging human fibroblasts MRC-5) p53 expression was down-regulated in a dose-dependent manner. Further studies have shown that may be related to the rise of SIRT1 white. Molecular docking simulation results showed that the role of echinacoside may be superior to another recognized anti-aging agent resveratrol. Echinacoside may be a potential compound that regulates cellular senescence.