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比较了６种含有氟及微量元素的防龋制剂对牙釉质脱钙的影响，同时观察了早期龋形成过程中釉质脱钙与时间的关系．选择牛牙８４颗，分为７组．实验组分别用含有等量氟离子的氟化锶、氟化亚锡、氟钼酸铵、氟化锌、氟化镧、氟化钠及去离子水处理，所有样本浸泡于乳酸液中形成人工釉质龋．对不同浸泡时间酸液中钙含量的测定表明，各组样本４８ｈ以前釉质脱钙量随时间的变化有所不同，４８ｈ以后酸液中钙含量趋于恒定．结果：氟化亚锡抑制釉质脱钙的能力最强，氟化钠最弱；酸蚀凝胶法形成人工龋时间约在４８ｈ左右；含氟及微量元素的防龋制剂能有效地抑制釉质脱钙，其机理可能是氟与微量元素的协同作用
The effects of six kinds of anti-caries preparations containing fluoride and trace elements on decalcification of enamel were compared. The relationship between enamel decalcification and time was also observed. Choose 84 teeth, divided into 7 groups. Experimental groups were treated with strontium fluoride, stannous fluoride, ammonium fluoromolybdate, zinc fluoride, lanthanum fluoride, sodium fluoride and deionized water containing the same amount of fluoride ions, respectively, and all the samples were soaked in lactic acid solution to form artificial Enamel caries. The determination of calcium content in acid at different soaking time showed that the amount of enamel decalcification changed with the time before 48h, and the content of calcium in the acid became constant after 48h. Results: Stannous fluoride inhibited enamel decalcification with the strongest ability and sodium fluoride was the weakest. The time of artificial caries formation by acid etching gel method was about 48h. Fluoride and trace element anticaries agents could effectively inhibit enamel detachment Calcium, its mechanism may be the synergy of fluorine and trace elements