论文部分内容阅读
本模型用本所发现的BALB/c小鼠自发性乳腺癌作瘤源,同源小鼠作宿主,连续皮下移植传代,目前已达21代.从移植第1代起,即出现自发肺、肝转移,其转移比数为3/3.移植第9代的连续动态病理切片观察表明,移植后11d即可见肺转移,而肝转移多发生在20d左右,30d以后肺、肝转移率均理高达100％.该肿瘤以血道转移为主;亦可见淋巴转移,92例中3例伴有淋巴转移.此外,移植肿瘤后第11天开始,宿主脾脏出现进行性肿大,巨脾症是本模型的重要特征之一.
This model found in our laboratory of spontaneous breast cancer BALB / c mice as tumor-derived, homologous mice as the host, continuous subcutaneous transplantation of passage, now up to 21 generations from the first generation of transplantation that spontaneous lung, Liver metastasis, the transfer ratio of 3 / 3. The 9th generation of continuous dynamic biopsy showed that after 11 days of transplantation can be seen in lung metastases, and liver metastases occurred in 20d or so, after 30d of lung and liver metastasis rate were Up to 100% .This tumor is mainly based on hematogenous metastasis; lymphatic metastasis can also be seen in 3 cases of 92 cases, accompanied by lymphatic metastasis.In addition, the first 11 days after tumor transplantation, the host spleen appeared progressive enlargement, splenomegaly is the One of the important features of the model.