目的观察探讨羊膜腔灌注术治疗妊娠中期不明原因严重羊水过少的临床疗效。方法选取行超声检查见羊水严重过少妊娠中期产检孕妇31例,首次灌注后行超声检查,统计分析妊娠结局。结果灌注效果满意者14例占45.16%,基本满意者11例占35.48%,无效者6例,占19.35%;无羊水者胎儿10例全部死亡,死亡率100%;羊水指数0~2 cm者15例中死亡13例,死亡率86.67%;羊水指数2~5 cm者4例全部存活,差异显著(P<0.05);检查可见胎儿发育不良者25例,正常者6例;引产者19例全部死亡,剖宫产10例,存活5例,阴道分娩2例,存活1例。结论行羊膜腔灌注术治疗妊娠中期不明原因严重羊水过少不仅能有效提高改善羊水环境,挽救胎儿生命,还能为超声诊断提供条件,为后续治疗提供依据。 Objective To investigate the clinical effect of amniotic cavity perfusion in the treatment of unexplained severe oligohydramnios in the second trimester of pregnancy. Methods Thirty-one pregnant women with severe oligohydramnios during the second trimester of pregnancy were selected by ultrasound examination. Ultrasound examination was performed after the first perfusion, and the pregnancy outcome was statistically analyzed. Results Fourteen cases with satisfactory perfusion accounted for 45.16%, 11 cases were basically satisfied with 35.48%, 6 cases were ineffective, accounting for 19.35%; 10 cases without amniotic fluid were all dead and the mortality rate was 100%; amniotic fluid index was 0-2 cm There were 13 deaths and 86.67% mortality in 15 cases. All 4 survivors with amniotic fluid index of 2 ~ 5 cm were significantly different (P <0.05). Twenty-five cases of fetal hypoplasia and 6 cases of normal fetuses All died, cesarean section in 10 cases, 5 cases of survival, vaginal delivery in 2 cases, 1 case of survival. Conclusion Amniotic fluid perfusion in the second trimester of pregnancy with severe unexplained oligohydramnios can not only effectively improve the amniotic fluid environment and save fetal life, but also provide the conditions for ultrasonic diagnosis and provide basis for follow-up treatment.