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目的探讨关节清理术与术后关节腔内注射透明质酸钠治疗大骨节病膝的疗效。方法 2004~2010年KBD膝关节病变患者754例882膝,行膝关节清理术,术后按是否使用透明质酸钠分成两组,比较疗效及不良反应,随访期限0.5~1.5 a。通过Lequesne指数评分对治疗前后的膝关节功能进行综合评价。结果两组治疗后Lequesne指数总评分均明显下降,与治疗前比较有统计学意义(P<0.05),A组Lequesne评分明显低于B组,组间比较差异有统计学意义(P<0.01);关节清理术组(B组)优良率为84.6%,而关节清理术加腔内注射透明质酸钠(A组)优良率达96.9%。结论关节清理术后关节腔注射透明质酸钠是治疗大骨节病膝的一种理想治疗方法。
Objective To investigate the effect of joint debridement and intra-articular injection of sodium hyaluronate on Kashin-Beck disease knees. Methods 754 patients (882 knees) from KBD patients with knee joint disease from 2004 to 2010 were divided into two groups according to whether they were treated with sodium hyaluronate. The curative effect and adverse reaction were compared between the two groups. The follow-up period was 0.5-1.5 years. Comprehensive evaluation of knee function before and after treatment was conducted by Lequesne index score. Results The total Lequesne index of the two groups were significantly decreased after treatment (P <0.05), the Lequesne score of group A was significantly lower than that of group B, the difference was statistically significant (P <0.01) . The excellent and good rate of articular debridement was 84.6% in group B, and 96.9% in articular debridement plus intra-articular injection of sodium hyaluronate (group A). Conclusion Intra-articular injection of sodium hyaluronate after joint debridement is an ideal treatment for Knee Joint Knee Disease.