一次ip醋酸镉2.4mg/kg、醋酸铅100mg/kg或氯化汞 2.0 mg/kg均可抑制大鼠肝微粒体药物代谢酶。上述处理还可明显降低苯巴比妥对肝微粒’乙基吗啡N-脱甲基化酶、氨基比林N-脱甲基化酶、苯胺羟化酶和环己巴比妥羟化酶活力的诱导作用,降低苯巴比妥对细胞色素P450和细胞色素 b_5以及微粒体蛋白合成的诱导作用。结果提示镉、铅、汞可能通过降低微粒体酶的新生合成,抑制肝微粒体药物代谢酶。 Once ip ip 2.4 mg / kg, lead acetate 100 mg / kg or mercuric chloride 2.0 mg / kg all inhibited rat liver microsomal drug metabolizing enzymes. The above treatment can also significantly reduce the phenobarbital on liver particles’ ethylmorphine N-demethylase, aminopyrine N-demethylase, aniline hydroxylase and cycloheximide hydroxylase activity The induction of phenobarbital on cytochrome P450 and cytochrome b_5 and microsomal protein synthesis induction. The results suggest that cadmium, lead and mercury may inhibit the metabolism of liver microsomes by reducing the nascent synthesis of microsomal enzymes.