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采用放射免疫法测定100例女性及17例男性狼疮性肾炎血中性激素水平。发现男、女病人雌的二醇水平(E_2)、黄体生成素(LH)及卵泡刺激素水平(FSH)均明显升高,而睾酮(T)水平无明显变化。病变活动者E_2水平明显高于病情稳定者;34例女性病人雷公藤治疗前后E_2水平差异极显著(P<0.01)治疗后E_2水平明显下降,临床有效率达90.9%。
Radioimmunoassay was used to determine the serum levels of sex hormones in 100 women and 17 male lupus nephritis patients. It was found that the male and female patients had significantly higher levels of diol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH), while the level of testosterone (T) did not change significantly. The level of E_2 in patients with active lesion was significantly higher than that in patients with stable disease. The E_2 levels in 34 female patients before and after treatment were significantly different (P <0.01). The level of E_2 decreased significantly after treatment, with a clinical effective rate of 90.9%.