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本文选用犬不同部位肠瘘给药法,比较肠管不同部位对酒石酸锑钾(以下简称T.E.)刺激敏感性的差异。用犬肠瘘给药测末梢血锑含量及在位肠襻给药测肠襻中残存锑量法,分析肠管不同部位对T.E.的吸收能力,并观察了大白鼠肠腔经酸化后对T.E.吸收的影响。实验结果:肠管不同部位对T.E.刺激的敏感性及吸收能力均有明显的差别。十二指肠及空肠对T.E.刺激敏感,呕泻反应强烈而频繁,但对T.E.的吸收量较多。迴肠下段及结肠对T.E.刺激感受迟钝,反应轻,次数少,仅有排粪(非泻)无呕吐,对T.E.的吸收量亦比肠管上段显著为低。人工降低肠pH,可显著提高肠管对T.E。的吸收量。
In this paper, different parts of the intestinal fistula administration method to compare the different parts of the bowel on the antimony potassium tartrate (hereinafter referred to T.E.) to stimulate the sensitivity of the difference. The content of antimony in the peripheral blood was measured by canine intestinal fistula administration and the residual antimony in the intestinal loop was measured by intestinal administration. The absorption capacity of TE in different parts of the intestine was analyzed, and the TE absorption Impact. Experimental results: Different parts of the intestine to T.E. stimulus sensitivity and absorption capacity were significantly different. The duodenum and jejunum were sensitive to T.E. stimulation, vomiting and diarrhea reaction was strong and frequent, but the amount of T.E. absorbed more. Lower esophagus and colon of T.E. irritation slow, mild reaction, the number of fewer, only defecation (non-diarrhea) vomiting, the absorption of T.E. also significantly lower than the upper intestine. Manually reducing intestinal pH, can significantly improve the bowel of T.E. Absorption.