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微血管病性溶血性贫血(MHA)是纤维蛋白在微血管内沉着,或因某种病变使微血管及其内膜上皮细胞异常,使通过的红细胞受机械损害,形成畸形红细胞和破碎红细胞,出现于外周血中,并引起明显溶血性贫血的一组疾病.本病是1962年由Brain Dacie等首先报道,并引入MHA这一疾病概念,提出其基础疾病有转移癌、血栓性血小板减少性紫癜(TTP)、恶性高血压、肾皮质坏死、结节性动脉周围炎、急性肾炎、系统性红斑狼疮(SLE)等.在日本自1966年首例报告以来,到1987年的20年间,根据医学中央杂志检索到的158例MHA(除TTP之外),作综合分析.病例在158例中,癌137例(86.7%),癌以
Microangiopathic hemolytic anemia (MHA) is fibrin deposition in the microvascular, or due to a certain lesion of the microvascular and its intimal epithelial cells abnormalities, so that through the red blood cells by mechanical damage, the formation of deformed red blood cells and broken red blood cells appeared in the periphery Blood, and cause a significant group of hemolytic anemia disease.This disease was first reported by Brain Dacie et al 1962 and the introduction of the concept of the disease, put forward its underlying diseases are metastatic cancer, thrombotic thrombocytopenic purpura (TTP ), Malignant hypertension, renal cortical necrosis, periarteritis nodosa, acute nephritis, systemic lupus erythematosus (SLE), etc. In Japan, the first report since 1966, to 20 years in 1987, according to the Medical Central magazine A total of 158 MHA (except TTP) were retrieved for a comprehensive analysis of 158 cases, with 137 (86.7%) cancers