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目的:探讨在乙型肝炎患者中,进行甲状腺功能指标检测的临床价值。方法:选取2013年7月-2014年6月本院收治的乙型肝炎患者75例作为研究对象,按照病程严重程度分为A组(21例,轻度乙型肝炎)、B组(27例,中度乙型肝炎)、C组(18例,重度乙型肝炎)、D组(9例,肝硬化),另外选取同期体检健康人员作为对照组,比较各组之间甲状腺功能指标的检测结果。结果:观察组治疗前的反式甲状腺激素3(rT3)、促甲状腺激素(TSH)、总甲状腺激素3(TT3)、总甲状腺激素4(TT4)、游离甲状腺激素3(FT3)、游离甲状腺激素4(FT4)指标均明显降低,rT3指标明显升高,差异有统计学意义(P<0.05)。治疗后患者各项指标均有所改善,但差异不大。其中C、D组的TSH、TT3、TT4、FT3、FT4指标仍明显低于对照组,rT3指标明显高于对照组,差异有统计学意义(P<0.05)。结论:和健康人群相比,乙型肝炎患者的甲状腺功能指标存在明显的异常,且随着病情的发展而不断变化。检测患者的各项指标,对于临床诊断和疗效评估具有重要的应用价值。
Objective: To investigate the clinical value of detecting thyroid function in hepatitis B patients. Methods: Seventy-five patients with hepatitis B admitted to our hospital from July 2013 to June 2014 were selected and divided into group A (21 patients with mild hepatitis B) and group B (27 patients , Moderate hepatitis B), C group (18 cases of severe hepatitis B) and D group (9 cases of liver cirrhosis). In the same period, healthy people in the same period were selected as the control group to compare the thyroid function indexes result. Results: The levels of rT3, TSH, TT3, TT4, FT3, free thyroid hormones, 4 (FT4) were significantly decreased, rT3 index was significantly increased, the difference was statistically significant (P <0.05). After treatment, the indicators of patients have improved, but little difference. The indexes of TSH, TT3, TT4, FT3 and FT4 in groups C and D were still significantly lower than those in control group, and the indexes of rT3 were significantly higher than those in control group (P <0.05). CONCLUSION: Compared with healthy people, there are obvious abnormalities in thyroid function indexes in patients with hepatitis B, and they are constantly changing with the development of the disease. Detection of the patient’s indicators, for clinical diagnosis and evaluation of the efficacy of an important application.