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目的探讨肺血管球瘤(GT)的临床病理特征、免疫组化表型及鉴别诊断。方法分析3例外科治疗的肺血管球瘤患者临床病理和影像学检查资料,对手术切除的肿瘤标本进行常规病理组织学和免疫组化检查,并复习相关文献,探讨其临床病理特征。结果 3例患者中,男性2例,女性1例,年龄42~58岁。组织学上,肿瘤组织由小血管及周围的肿瘤细胞组成,瘤细胞丰富,圆形、卵圆形,形态较一致,胞质丰富红染或透亮,无明显异型性和核分裂象,间质明显黏液变性、水肿。免疫组化染色示瘤细胞vimentin、SMA(+),Cg A、Syn、CD34、CD99、HMB45和CK(-)。结论肺血管球瘤非常罕见,临床表现为肺内占位性病变的相关症状或体征,该肿瘤的诊断依赖病理组织学及免疫组化检查,预后较好。
Objective To investigate the clinicopathological features, immunohistochemical phenotype and differential diagnosis of pulmonary glomus tumors (GT). Methods The clinicopathological and imaging findings of 3 patients with pulmonary angiomyoma were analyzed. The histopathological and immunohistochemical examination of the resected tumor specimens was performed. The related literatures were reviewed and the clinicopathological features were analyzed. Results Among the 3 patients, there were 2 males and 1 female, aged from 42 to 58 years. Histologically, the tumor tissue consists of small blood vessels and surrounding tumor cells, tumor cells rich, round, oval, more consistent morphology, rich red staining or translucent cytoplasm, no obvious atypia and mitosis, interstitial obvious Mucus degeneration, edema. Immunohistochemistry showed tumor cells vimentin, SMA (+), Cg A, Syn, CD34, CD99, HMB45 and CK (-). Conclusions Pulmonary glomeruloma is very rare. The clinical manifestations are related symptoms or signs of occupying lesions in the lung. The diagnosis of this tumor depends on histopathology and immunohistochemistry, and the prognosis is good.