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在一些乙肝表面抗原(HBsAg)阳性的乙肝患者血清中出现e抗原(HBeAg)与血清中存在有大量Dane颗粒、高活力DNA聚合酶有关,说明乙肝病毒(HBV)的复制活跃,传染性强。凡血清中无HBeAg或有抗-HBe的人,一般来讲循环病毒较少,即其传染性较弱,所以检查HBeAg和抗-HBe在临床上具有重要的意义。科学家们对HBeAg的重视不仅在于它在临床和流行病学上的意义,同时也对它的结构与功能的关系感到兴趣。至今为止,HBeAg基因在HBV DNA序列上的位置尚未确定,HBeAg与核心抗原(HBcAg)结构间
In some hepatitis B surface antigen (HBsAg) -positive hepatitis B patients with serum e antigen (HBeAg) and the presence of a large number of serum Dane particles, high-activity DNA polymerase, indicating that the replication of hepatitis B virus (HBV) active, highly contagious. Where serum HBeAg-free or anti-HBe, generally speaking less circulating virus, that is, its infectivity is weak, so the examination of HBeAg and anti-HBe is clinically important. The importance that scientists attach to HBeAg lies not only in its clinical and epidemiological implications, but also in its structural and functional relationships. Up to now, the location of HBeAg gene in HBV DNA sequence has not been determined. The relationship between HBeAg and core antigen (HBcAg)