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血氧饱和度(SO_2)为临床观察病情变化提供了有意义的指标。传统血氧饱和度检测研究工作多采用双光源和多光源光电容积脉搏波描记法实现无创检测来减少病人痛苦。通过研究生物组织对光的吸收和散射特性,将光谱学和光声技术相结合提出了一种无创式单光源检测血氧饱和度(SO_2)、脱氧血红蛋白浓度[HBR]和氧合血红蛋白浓度[HbO_2]的新方法。该方法基于血液对光信号的吸收和散射理论基础和光声信号呈现吸收线形关系建立单波长光声光谱血氧饱和度检测技术,不仅可以进行指标性参数分析还可以对组织成像。为了验证该技术可行性,在实验中采用单波长激光脉冲光源,以绿色和红色墨水的混合液体作为含有脱氧血红蛋白和氧合血红蛋白的血液模型注入软管模拟人体血液环境。其中红色墨水的含量类比于血液中含氧血红蛋白含量,从而可通过测量计算出红色和绿色墨水浓度来表征伪血氧饱和度(poseudo-SO_2)。实验结果表明,所测的伪血氧饱和度与实际浓度误差不超过6.97%,采用该方法量化血氧饱和度是可行的;同时利用实验结果,结合光声成像技术完成了对伪血液中单圆管截面成像。该方法替代多波长光谱分析的方法能显著降低激光系统和便携式实现成本。
Oxygen saturation (SO 2) provides a meaningful indicator of clinical changes in the condition. Traditional oxygen saturation detection research and more use of dual light source and multi-light source photoplethysmography to achieve noninvasive detection to reduce patient pain. By studying the absorption and scattering properties of light by biological tissues, a novel noninvasive single light source was proposed based on the combination of spectroscopy and photoacoustic technology to detect the oxygen saturation (SO 2), deoxy-hemoglobin concentration [HBR] and oxyhemoglobin concentration [HbO 2 ] New method. Based on the theory of blood absorption and scattering of light signal and the absorption linear relationship of photoacoustic signal, this method establishes the single-wavelength photoacoustic spectroscopy oxygen saturation detection technology, which not only can make the index parameter analysis but also can make the tissue imaging. In order to verify the feasibility of the technique, a single-wavelength laser pulse light source was used in the experiment to inject a mixture of green and red inks as a blood model containing deoxy-hemoglobin and oxy-hemoglobin into a human blood to simulate the human blood environment. Where the red ink content is analogous to the oxygenated hemoglobin content in the blood so poseseudo-oxygen saturation (poseudo-SO_2) can be characterized by measuring the red and green ink concentrations. The experimental results show that the measured false oxygen saturation and the actual concentration error does not exceed 6.97%, using this method to quantify oxygen saturation is feasible; at the same time using the experimental results, combined with photoacoustic imaging technology to complete the pseudo-blood single Circular tube section imaging. This approach to multi-wavelength spectral analysis can significantly reduce laser system and portable implementation costs.