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目的研究肝炎肝硬化患者红细胞 CR1粘附活性与肝功能损伤严重程度的相关性。方法采用红细胞天然免疫粘附肿瘤细胞的测定方法对88例肝炎肝硬化病人、30例正常人的红细胞 CR1分子粘附活性进行测定,5个或以上红细胞牯附1个肿瘤细胞为一个结合单位,计算粘附率。结果肝炎肝硬化患者红细胞 CR1分子粘附活性显著低于正常人群(P<0.01),失代偿性肝硬化患者的红细胞 CR1分子粘附活性显著低于代偿性肝硬化患者(P<0.01),肝炎肝硬化患者红细胞 CR1分子粘附活性的变化与胆碱酯酶(CHE)密切相关,按 Child Pugh 分级。肝炎肝硬化患者随 Child 积分的升高,其红细胞 CR1分子粘附活性相应下降。结论肝炎肝硬化病人红细胞CR1分子粘附活性的变化与其病情的严重程度密切相关,该项可作为判断肝病患者肝功能损伤程度的重要指标。
Objective To investigate the correlation between the adhesion activity of erythrocyte CR1 and the severity of liver injury in patients with liver cirrhosis. Methods The adhesion activity of erythrocyte CR1 molecules in 88 patients with cirrhosis and 30 normal controls were determined by the method of innate immunity adhering to erythrocytes. One or more tumor cells of 5 or more erythrocytes were combined into one unit, Calculate the adhesion rate. Results The adhesion activity of erythrocyte CR1 in patients with cirrhosis was significantly lower than that in normal people (P <0.01). The adhesion activity of CR1 in patients with decompensated cirrhosis was significantly lower than that of patients with compensated cirrhosis (P <0.01) , Changes in erythrocyte adhesion activity of erythrocyte CR1 in cirrhotic patients were closely related to cholinesterase (CHE), according to Child Pugh classification. Patients with hepatitis cirrhosis increased with Child’s score, the corresponding adhesion activity of erythrocyte CR1 molecules decreased accordingly. Conclusion The changes of erythrocyte adhesion activity of CR1 in cirrhotic patients with liver cirrhosis are closely related to the severity of the disease, which can be used as an important index in judging the degree of liver injury in patients with liver cirrhosis.