随机调查不育专科门诊男性病人４８６例，经体检和运用显微摄影、Ｍａｋｌｅｒ计算盘观察病人精子密度、运动速度和活动率等，结果表明，父亲年龄≥４０岁时出生的５８例男性中，无精子症发病率为３２．８％，少精子症发病率为２５．９％，与父亲＜３９岁年龄组相比，差异显著（Ｐ＜０．０１）；精子密度、运动速度、顶体完整率在父亲≥４０岁组也明显低于父亲＜３９岁年龄组。 Randomly investigating 486 male patients with infertility specialist outpatients, the physical examination and the use of microscopy, Makler calculation disk observation of patient sperm density, exercise speed and activity rate, the results show that the father of 40 years old or older born in 58 men, The incidence of azoospermia was 32.8%, and the incidence of oligozoospermia was 25.9%, which was significantly different from that of the father <39 years old (P <0.01). The sperm density, exercise speed, The complete rate was significantly lower in the father 40 years old than in the father 39 years old.