论文部分内容阅读
分别测定了急性肝炎19例、慢性迁延型肝炎20例、慢性活动型肝炎17例、活动性肝硬化20例的血清T—SOD、Mn—SOD、CuZn—SOD活性,且与42例正常人进行对比分析。结果发现病毒性肝炎各组T—SOD活性为44.09±7.26～47.28±9.09、Mn—SOD活性为12.24±3.53～13.37±3.91明显低于正常组(52.23±5.53、16.92±2.85)(P<0.05～0.01);各肝炎组与正常组CuZn—SOD活性无差异(P<0.05)。结果提示肝炎病T—SOD的下降与Mn—SOD下降有密切关系,SOD下降导致氧自由基在体内蓄积,参与肝细胞的损伤、肝纤维化及癌变发生。
T-SOD, Mn-SOD and CuZn-SOD activities of 19 patients with acute hepatitis, 20 patients with chronic persistent hepatitis, 17 patients with chronic active hepatitis and 20 patients with active cirrhosis were measured and compared with 42 normal subjects Comparative analysis. The results showed that the activity of T-SOD in viral hepatitis group was 44.09 ± 7.26 ~ 47.28 ± 9.09 and the activity of Mn-SOD was 12.24 ± 3.53 ~ 13.37 ± 3.91, which was significantly lower than that of the normal group (P <0.05) ~ 0.01). There was no difference in CuZn-SOD activity between hepatitis group and normal group (P <0.05). The results suggest that the decrease of T-SOD in hepatitis is closely related to the decrease of Mn-SOD. The decrease of SOD leads to the accumulation of oxygen free radicals in the body, which is involved in the damage of hepatocytes, liver fibrosis and carcinogenesis.