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目的 :观察大剂量维生素C早期干预重症感染儿童器官损害的临床效果。方法 :将 92例重症感染患儿随机分为治疗组和对照组。治疗组在与对照组统一综合治疗标准的基础上早期加用大剂量维生素C 2 0 0～ 5 0 0mg/kg .d ,观察用药后临床症状、心肌酶、肝功能和心电图的恢复情况 ,记录住院时间。结果 :治疗组临床症状改善时间、住院时间、CK -MB、LDH、ALT、AST、r -GT以及心电图的恢复均明显优于对照组 ,两组对比差异有非常显著的意义 (P <0 .0 1)。结论 :大剂量维生素C早期应用于重症感染病人安全、效果好 ,可干预重症感染器官功能损害 ,促进其恢复。
Objective: To observe the clinical effect of high dose vitamin C on organ damage in children with severe infection at early stage. Methods: 92 children with severe infection were randomly divided into treatment group and control group. The treatment group was treated with high-dose vitamin C 200 ~ 500 mg / kg. D on the basis of the unified comprehensive treatment standard with the control group, and the recovery of clinical symptoms, myocardial enzymes, liver function and electrocardiogram was observed and recorded Hospitalization time. Results: The improvement of clinical symptoms, length of hospital stay, recovery of CK-MB, LDH, ALT, AST, rGT and electrocardiogram in the treatment group were significantly better than those in the control group, with significant differences between the two groups (P <0. 0 1). Conclusion: The early application of high-dose vitamin C in patients with severe infections is safe and effective, which can interfere with organ dysfunction and promote the recovery of severe infections.