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目前发展的许多头孢菌素类抗生素中,它们的血清半衰期(T_(1/2))大多不超过1～2小时,而对一些革蓝氏阴性菌感染特别是严重感染如绿脓杆菌感染,需要在感染部位保持持续性杀菌水平。因此,对于这些头孢菌素,要求长期保持有效血药浓度就必须经常给药,这常会引起臀部不适或刺激静脉,增加患者的痛苦,在儿童和门诊患者中尤其显得突出。因此,具持续血药浓度的长效头孢菌素是非常受欢迎的。一方面,延长血清半衰期可延长药物在感染部位如脑脊液,外科领
Many current cephalosporin antibiotics, their serum half-life (T_ (1/2)) are mostly not more than 1 to 2 hours, but for some Gram-negative bacteria infections, especially serious infections such as Pseudomonas aeruginosa infection, Need to maintain the level of sustained sterilization at the site of infection. Therefore, for these cephalosporins, requiring long-term maintenance of effective plasma concentrations must be frequently administered, which often causes hip discomfort or irritation of the veins, increases the patient’s pain and is particularly pronounced in children and outpatients. Therefore, long-acting cephalosporins with sustained plasma concentrations are very popular. On the one hand, prolonging serum half-life can prolong the drug’s exposure to sites such as cerebrospinal fluid and surgical collar