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目的 :比较丙种球蛋白治疗川崎病两种用药方案的治疗效果。方法 :单剂疗法组 2 0例 ,五日疗法组44例 ,分别比较两组患儿的总热程、退热时间、住院时间及冠状动脉损害发生率。结果 :总热程分别为 8 9± 2 7天、 10 0± 3 4天 ;退热时间分别 2 1 3± 2 3 5小时、 47 9± 31 3小时 ;住院时间分别为 6 6± 4 0天、 11 5± 4 8天 ,前者比后者均明显缩短 (P <0 0 5 )。冠状动脉损害发生率分别为 5 2 %、 5 9%。两者差异无显著性 (P >0 0 5 )。结论 :两种用药方案均可预防发生冠状动脉损害 ,但在快速退热、减轻症状、缩短住院时间等方面单剂疗法比五日疗法更显著。
Objective: To compare the therapeutic effects of gamma globulin on Kawasaki disease. Methods: 20 patients in the single-dose therapy group and 44 patients in the 5-day therapy group were used to compare the total heat history, the antipyretic time, the length of hospital stay and the incidence of coronary artery lesions in both groups. Results: The total heat was 8 9 ± 2 7 days, 10 0 ± 34 days respectively; the antipyretic time was 21 3 ± 23 5 hours and 47 9 ± 31 3 hours respectively; the length of hospital stay was 6 6 ± 40 Day, 115 ± 48 days, the former was significantly shorter than the latter (P <0 05). The incidence of coronary artery lesions were 52%, 59%. There was no significant difference between the two groups (P> 0.05). Conclusion: Both of the two regimens can prevent coronary artery injury, but single dose therapy is more effective than the fifth day therapy in the aspects of rapid fever, relieve symptoms and shorten the hospital stay.