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黏膜相关淋巴组织结外边缘带B细胞淋巴瘤(MALT淋巴瘤)具有独特的病因学机制和分子遗传学改变,是继弥漫性大B细胞淋巴瘤和滤泡性淋巴瘤,发病率排在第3位的非霍奇金B细胞性淋巴瘤。日常临床病理工作中,根治性标本结合形态学和免疫组化染色,诊断并不困难;但是,小活检标本却易造成漏诊和误诊。深入了解MALT淋巴瘤发生、发展过程中的病因学基础和特征性的分子遗传学异常,将分子病理学诊断技术应用到临床病理实践中,对于疾病的诊断和鉴别诊断,以及后续治疗具有重要意义。
Mucosal-associated lymphoid tissue extranodal marginal zone B-cell lymphoma (MALT lymphoma) has a unique etiology and molecular genetic changes, is the second largest diffuse large B-cell lymphoma and follicular lymphoma, the incidence ranked in 3-digit non-Hodgkin’s B-cell lymphoma. In routine clinical and pathological work, the combination of radical specimens and morphological and immunohistochemical staining is not difficult to diagnose; however, small biopsy specimens are likely to cause missed diagnosis and misdiagnosis. In-depth understanding of the pathogenesis of MALT lymphoma, the etiology of the process of development and characteristic molecular genetic abnormalities, molecular pathology diagnostic techniques applied to clinical pathology practice, for the diagnosis and differential diagnosis of disease, and follow-up treatment of great significance .