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肿瘤坏死因子-α(TNF-α)是一种具有广泛生物学活性的细胞因子,在脑缺血及脑缺血再灌注损伤中的作用日益受到重视。在机体内,单核巨嗜细胞可产生 TNF-α,神经系统的神经元、星形胶质细胞和小胶质细胞也能产生 TNF-α,并且在脑缺血中的作用极为复杂,现就近几年国内外有关此方面的作用做一简要综述。1 生物学特性TNF-α是一种具有广泛生物学功能的多肽类细胞因子,主要由单核巨噬细胞产生。在中枢神经系统中,神经元、星形细胞、胶质细胞也可产生 TNF-α。人的 TNF 基因位于第6对染色体上,与 HLA 基因连锁。人 TNF-α基因表达产物首先是由233个氨基酸
Tumor necrosis factor-α (TNF-α) is a kind of cytokines with a wide range of biological activity, and its role in cerebral ischemia and cerebral ischemia-reperfusion injury is gaining more and more attention. Mononuclear macrophages produce TNF-α in the body, and neuronal, astrocyte and microglial cells also produce TNF-α, and their role in cerebral ischemia is extremely complex In recent years, the role of this area at home and abroad to make a brief overview. 1 Biological characteristics TNF-α is a polypeptide with wide biological function of cytokines, mainly produced by mononuclear macrophages. In the central nervous system, neurons, astrocytes, glial cells can also produce TNF-α. The human TNF gene is located on chromosome 6 and is linked to the HLA gene. The human TNF-α gene expression product is first composed of 233 amino acids