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目的：主要是探讨急性脑血管病患者病变性质、严重程度与血浆内皮素－1（ET－1）浓度的关系。方法：应用放射免疫方法测定87例急性脑血管病人血浆ET－1浓度并与42例正常人进行比较。结果：脑出血与脑梗塞组血浆ET－1浓度明显高于对照组（P＜0．001），而脑梗塞组血浆ET－1浓度比脑出血组升高，但未有统计学意义（P＞0．05）。急性脑血管病重型者比轻型者血浆ET－1浓度明显升高（P＜0．01），合并高血压者血浆ET－1浓度较正常对照组显著升高（P＜0．001），而与血压正常组相比较二者无显著性差异（P＞0．05）。结论：提示急性脑血管病患者血浆ET－1浓度升高与病变严重程度、血压升高有一定关系，与病变性质虽无统计学意义，但脑梗死者也较脑出血组升高，表明ET－1作为一种内源性血管活性肽在急性脑血管病的预后和发病机制方面是一种有害的介质。
Objective: To investigate the relationship between the nature and severity of lesions and plasma endothelin-1 (ET-1) levels in patients with acute cerebrovascular disease. Methods: Plasma ET-1 levels in 87 patients with acute cerebrovascular disease were measured by radioimmunoassay and compared with 42 healthy controls. Results: The plasma concentration of ET-1 in cerebral hemorrhage and cerebral infarction group was significantly higher than that in control group (P <0.001), but the concentration of ET-1 in cerebral infarction group was higher than that in cerebral hemorrhage group > 0.05). The plasma concentration of ET-1 in patients with severe cerebrovascular disease was significantly higher than that in patients with mild type of cerebrovascular disease (P <0.01), while the plasma concentration of ET-1 in patients with hypertension was significantly higher than that in controls (P <0.001) Compared with normal blood pressure group, there was no significant difference (P> 0.05). Conclusions: It is suggested that the plasma ET-1 concentration in patients with acute cerebrovascular disease has a certain relationship with the severity of the disease and the increase of blood pressure. Although the nature of the disease is not statistically significant, the patients with cerebral infarction also have higher levels of ET- -1 as an endogenous vasoactive peptide is a detrimental mediator in the prognosis and pathogenesis of acute cerebrovascular disease.